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KMID : 1009020210190010155
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Clinical Psychopharmacology and Neuroscience
2021 Volume.19 No. 1 p.155 ~ p.159
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Positive Symptoms in Antipsychotic-naive Schizophrenia are Associated with Increased Body Mass Index after Treatment
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Lin Shih-Hsien
Tseng Huai-Hsuan
Tsai Hsin Chun
Chi Mei Hung
Lee I Hui
Chen Po See
Chen Kao Chin
Yang Yen Kuang
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Abstract
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Objective: Weight gain is an important risk factor for morbidity and mortality among patients with schizophrenia. We speculated that positive symptoms, related to dopaminergic hyperactivity and altered mesolimbic function, are associated with weight gain.
Methods: Twenty-two antipsychotic-naive, first-episode patients with schizophrenia were enrolled. The Positive and Negative Syndrome Scale was completed at enrollment and follow-up. Body mass index (BMI) was also measured.
Results: The increase in BMI, after 6.04 ± 2.16 years of follow-up, was associated with positive symptoms, but not negative symptoms, before treatment with antipsychotics in antipsychotic-naive patients with schizophrenia.
Conclusion: This finding implied that dopaminergic hyperactivity could be an important factor to predict the treatment outcome. Body weight control is important for the health management of patients with schizophrenia with more severe positive symptoms.
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KEYWORD
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Mesolimbic pathway, Metabolic syndrome, Positive syndrome, Schizophrenia, Weight gain
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